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1. G1D 101- An Introduction
2. Treatment of G1D
3. Common questions after the diagnosis of G1D
4. G1D Research
5. Movement disorders in G1D
Once the diagnosis of G1D is confirmed, it is not uncommon for parents to feel both a sense of relief now knowing the actual cause for their child's symptoms as well as a sense of urgency to learn as much as possible about the treatment and management of the disorder. Because there is still so much more to learn about this rare disorder, treating and managing the condition is a life-long learning process for both families and their physicians. Families are therefore encouraged to develop strong collaborative relationships with their physicians. It is encouraging that the number of families and health care professionals interested in the disease is growing rapidly and significant advances and changes in the way we think about G1D may come in the near future.
No other disease associations are known at this time.
Common but easily treatable side effects of the diet include constipation, poor weight gain, and possible kidney stones. It is important to talk to your doctor about how to reduce these possible side effects. Also, because the diet does not provide all the necessary vitamins and minerals of a well balanced diet, a vitamin supplement may be indicated.
For unknown reasons, some patients with G1D have been able to successfully discontinue the diet at the onset of puberty. Others have remained on the diet and others resume treatment with seizure and other medications to reduce their symptoms.
Since most cases of G1D are a result of a new spontaneous mutation that occurs at the time of conception and nothing a parent did or did not do caused this to happen, there is no way to know if a child is at risk of having the disorder. Unless a disease causing mutation has been previously identified in a family at risk to have a child with G1D, there is no prenatal test to determine if a child will be born with G1D. Prenatal ultrasounds and current mandatory newborn screening tests do not detect G1D. If a disease causing mutation is known, prenatal diagnosis (amniocentesis or chorionic villus sampling) and possible preimplantation genetic diagnosis (the combination of in vitro fertilization and genetic testing to identify unaffected embryos) would be available.
More research is needed. At the moment, there is no evidence that the brain will allow the introduction of normal DNA or cells capable of replacing the abnormal brain cells affected by G1D. New developments and advances in gene therapy are expected in the future.
All the information contained herein was made possible by the collaboration between The Child Brain Foundation, Dr. Juan M. Pascual, and The National Institute of Health's Office of Rare Diseases Research (Collaboration, Education and Test Translation Program).
You may not commercially exploit any of the contents. Any redistribution or reproduction of part or all of the contents in any form is allowed and encouraged and proper acknowledgement is urged. To properly acknowledge the information contained here, please add the following to any excerpt or copy:
"We acknowledge The Child Brain Foundation, www.childbrainfoundation.org, as the organizer, Dr. Juan Pascual as the author, and The National Institute of Health's Office of Rare Diseases Research (Collaboration, Education and Test Translation program, CETT Program) as the sponsor of this information."